Weight gain occurs when fat in food is reabsorbed back to the body. Orlistat works by blocking the enzymes in your gut that digest fat. The fat is passed out of the body as stool. By blocking nearly a third of the fat, you eat, absorbed body fat is reduced and does not add to your weight. Excess weight can increase the chances of health issues such as cholesterol, diabetes, and heart attacks. Orlistat helps to reduce obesity. For best results, take the Orlistat alongside a low-fat diet and exercise.
Warnings
Orlistat may modify the activity of certain drugs. Make sure you speak to your doctor before using Orlistat if you are on other medications. Orlistat may unbalance an anticonvulsant treatment by decreasing the absorption of antiepileptic drugs, thus leading to convulsions.
Directions
Take the tablets 3 times daily for 7 days 1 hour after a meal. If you skip a meal or eat a low-fat meal, there will be no fat to absorb. You, therefore, do not need to swallow Orlistat capsules.
Ingredients
Each capsule contains the active ingredient Orlistat 120 mg. Orlistat capsules contain the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. Each capsule shell contains gelatin, titanium dioxide, and FD&C Blue No.
Side Effects
At the start of taking Orlistat capsules, you may experience some side effects. They include: Abdominal pains. Bloating or wind. The urgent need to open the bowels. Liquid stools filled with fat or oil.
💊 Orlistat 120 mg Side Effects: What You Need to Know Before Starting Treatment
When it comes to effective, clinically proven weight-loss medication, Orlistat 120 mg (also known by the brand name Xenical) is one of the most widely prescribed options. It works by preventing your body from absorbing some of the fat you eat, helping you lose weight safely when combined with a balanced, low-fat diet.
However, as with any medicine, it’s important to understand the potential side effects that can occur while taking Orlistat. Knowing what to expect helps you stay prepared and make informed decisions about your health.
🧬 How Orlistat Works
Orlistat 120 mg acts locally in your digestive system. It blocks the enzyme lipase, which breaks down dietary fat. As a result, around one-third of the fat you consume passes through your body undigested, reducing your calorie intake.
While this process helps with weight loss, it also explains why most of the side effects are related to digestion and bowel habits.
⚠️ Common Side Effects of Orlistat 120 mg
The majority of people experience mild to moderate side effects, especially during the first few weeks of treatment. These effects are most noticeable when your diet is high in fat.
Here are the most common ones:
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Oily or fatty stools – due to undigested fat leaving the body.
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Increased bowel movements – you may notice a need to use the toilet more often.
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Flatulence with oily discharge – passing gas that may include small amounts of oil.
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Urgent need to use the bathroom – sometimes with difficulty holding it in.
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Abdominal pain or discomfort – often mild and short-lived.
💡 Tip: You can significantly reduce these effects by limiting your fat intake to less than 30 % of your total daily calories.
⚠️ Less Common Side Effects
A smaller number of people experience side effects such as:
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Bloating or mild stomach cramps
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Soft or loose stools
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Tooth or gum discomfort
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Headache
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Fatigue or low energy
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Irregular menstrual cycles
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Anxiety or mild mood changes
These usually improve over time as your body adjusts to the medication and as you refine your diet.
⚠️ Rare but Serious Side Effects
Although rare, some people may experience more serious side effects that require medical attention:
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Severe abdominal pain (may indicate gallstones or pancreatitis)
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Yellowing of the skin or eyes (a possible sign of liver problems)
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Dark urine or pale stools
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Severe allergic reactions, such as rash, itching, swelling, or difficulty breathing
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Severe rectal bleeding
If any of these symptoms occur, stop taking Orlistat and contact a healthcare professional immediately.
🧠 Vitamin Deficiency and Supplement Advice
Because Orlistat blocks fat absorption, it can also reduce the absorption of fat-soluble vitamins – A, D, E, and K.
To prevent deficiency, it’s recommended that you:
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Take a daily multivitamin supplement
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Take it at least two hours before or after your Orlistat dose (e.g., at bedtime)
This ensures your body still gets all the essential nutrients it needs while you’re losing weight.
🥗 Diet Tips to Minimise Side Effects
You can make your Orlistat experience much smoother by following a few simple dietary habits:
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Stick to a low-fat, calorie-controlled diet
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Avoid fried foods and high-fat snacks
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Divide your daily fat intake evenly across meals
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Stay hydrated – drink plenty of water
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Plan meals carefully to prevent sudden digestive upset
By making these small adjustments, you’ll not only reduce uncomfortable side effects but also maximise your weight-loss results.
⚖️ Is Orlistat Right for You?
Orlistat 120 mg is usually prescribed for adults with a BMI of 30 or higher, or BMI 27 and above if other health risks (like type 2 diabetes or high blood pressure) are present.
It’s important to use it under the guidance of a qualified healthcare professional, especially if you take other medications.
✅ Final Thoughts
Orlistat 120 mg is a proven and effective weight-loss medication — but understanding and managing its side effects is key to success.
Most people find that any discomfort improves with time and the right diet choices.
If you’re consistent, patient, and mindful of your meals, Orlistat can be an excellent tool in your weight-management journey.





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